Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
It's the summer of 1983, and precocious 17-year-old Elio Perlman is spending the days with his family at their 17th-century villa in Lombardy, Italy. He soon meets Oliver, a handsome doctoral student who's working as an intern for Elio's father. Amid the sun-drenched splendor of their surroundings, Elio and Oliver discover the heady beauty of awakening desire over the course of a summer that will alter their lives forever.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Boston Consulting Group could also be poised to make a change given its managing partner, Richard Lesser, is due to come to the end of his second term in October. His future is unclear, however, as the firm declined to comment on its election process or how many terms its leader can serve.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
If you’re looking for a free CRM system, Zoho is probably the one for you. Why? It comes down to the integration possibilities. For example, Zoho integrates with JotForm and Unbounce simply by adding your API key. This means that within seconds, web leads will automatically be sent to your CRM. Pretty powerful for being free.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Create a mood board for inspiration, including quotes and pictures that will invigorate your creative juices. You might even want to change it up once and a while if you have a major project due or need fresh ideas. Art or wall décor can also add a creative touch to your workspace. We recommend the 3 in 1 Board, $19.95, at CB2.com (pictured above).
Housing started last year on a high note. It ended the year facing mounting worries about higher interest rates, supply constraints, tight credit and a host of other problems.
“FKA细枝”(FKA twigs)，《两星期》(Two Weeks)，Young Turks
A fascinating study from researchers at the University of North Florida reveals that running barefoot may actually improve your memory more than running with shoes. While most memory studies seem to take place in a laboratory or room where everyone sits at a table, this experiment definitely introduced an interesting idea to the search for a better memory. The experiment focused on something called "working memory," which is the human ability to process information and recall details throughout life. The scientists published the results of their study in "Perceptual and Motor Skills," and found that running barefoot resulted in a not-insignificant memory boost when compared with memory performance after running with shoes. The researchers found that tossing your shoes off and running for about 16 minutes at a comfortable pace could result in a 16% improvement in working memory performance.
Trends and targets in antiviral phototherapy
We will strive to boost employment and business startups.
The four megalopolises also saw fewer traffic jams after November due to reasons ranging from less travel in winter and smoggy days to the return of migrant workers to their hometowns.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
"The guy must have weighted the pros and cons of the situation: he had a great chance to survive a stranded elevator, but would have been doomed if he left homework undone," joked @Zealshifang.
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Whiteness, in this context, is more than just skin color. You could define it as membership in the “ethno-national majority,” but that’s a mouthful. What it really means is the privilege of not being defined as “other.”
ACE2 as a potential therapeutic target for pandemic COVID-19
The best bosses understand that there must be a balance between the company or client’s needs and the needs of his or her employees. The best bosses are willing to listen and talk about any issues an employee may be having because they understand that a happy employee is a more productive employee。
Diagnostic technologies for COVID-19: a review
To start with, a year before the first iPhone was released, LG had introduced a full touchscreen phone. Even that was not the first, though. The world's first touchscreen phone was IBM's Simon, which was released in 1992. And touchscreen technology even predates the Simon. The first touchscreen device was a tablet made by E.A. Johnson in 1965 that was used by air traffic controllers until 1995. Bent Stumpe and Frank Beck made the first capacitive touchscreen in the early '70s. Unlike Johnson's tablet, it could not be pressed with the fingers. Instead, it required a stylus. In 1971, Samuel Hurst developed the first resistive touchscreen, which he called the "elograph." It responded to the fingers as well as a stylus. In 1985, HP invented the world's first touchscreen computer, called the HP-150. In 1993, Apple also released its first touchscreen device—the Newton Personal Digital Assistant. The product was a flop, recording low sales.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Since April 2007, the value of the top 100 brands has increased by 106 per cent. That compares with a 61 per cent rise in the S&P 500 and growth of 21 per cent in the MSCI world index over the same period.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
喜剧类最佳女配角：凯特?麦金侬(Kate McKinnon)，《周六夜现场》(Saturday Night Live)
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Arlie Russell Hochschild, the author of “Strangers in Their Own Land: Anger and Mourning on the American Right,” describes a feeling of lost opportunity as the “deep story” of the rural Louisiana communities she spent four years studying.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
最后，今年只有两所学校首次登上开放课程排行榜。上海交通大学安泰经济与管理学院(Antai College of Economics and Management)直接排到第32名，而亚利桑那大学(University of Arizona)艾勒管理学院(Eller College of Management)在75所院校中排名第68位。
7) I am often in a bad mood 0 1 2 3 4
She pointed to equal pay, saying it's not "just a woman's issue" but something that affects everyone. "If you have a wife, a mother, a sister, a daughter who is working and they are not being treated fairly, the whole family suffers," Clinton said.
Influenza neuraminidase: A druggable target for natural products
Chinese Cultural Relics is a new journal that translates Chinese-language articles, originally published in the journal Wenwu, into English. The discovery of the 1,700-year-old cemetery was included in its inaugural issue.
The film is shot to mark the tenth anniversary of the television series, first released in 2005.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
If you do much hiring of freelancers, you’ve probably considered outsourcing the outsourcing. There are several great services that can help, each with varying business models. For example, Bolton Remotewill build your team with vetted, offshore contractors. Another provider,Hubstaff, starts with your project in mind and then matches you with project specialists. Using an outsourcing placement service will save time instead of trying to do the recruiting yourself. These firms typically offer free recruiting and placement services but take a cut of the hourly rate.
The role of biosensors in the detection of emerging infectious diseases
5. Women keep rising.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
明星们的私家飞机刚停稳，“老爹身材”一词便在互联网上走红。男性微胖的身材成为潮流，荧幕上不少这样的例子。法新社（AFP）Deborah Cole（黛博拉?科尔）写道：“杰拉尔?德帕迪约（Gerard Depardieu）在《爱之谷》中的形象便是“大汗淋漓、气喘吁吁地打着赤膊”， 华金?菲尼克斯 （Joaquin Phoenix）在 伍迪?艾伦（Woody Allen）的新片《非理性的人》（Irrational Man）中也露出了他那胖胖的肚子。科林?法瑞尔（Colin Farrell）出席《龙虾》（The Lobster）的首映红毯时，看起来如往常一般衣冠楚楚，然而在剧中他却大腹便便。为了给荒诞主义者欧格斯?兰斯莫斯（Yorgos Lanthimos）的黑色喜剧中的孤独主角增肥，法瑞尔大量进食高热量食品，其中包括融化了的冰淇淋。他告诉《好莱坞报道》（Hollywood Reporter），“在早晨10点享用2个芝士汉堡、薯条和可乐可不那么有趣，”他补充道，“不过我喜欢芝士汉堡。”
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Consoles: Xbox One, Xbox 360, PS4, PS4, PC
In truth, slower growth of about 8 per cent could be better for China and for the world. More environmentally sustainable and equitable outcomes would ease popular concerns and higher consumption would ease tensions over global trade.
Life Is Strange
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
These molds turn regular fruits into fun shapes.
Inhibition of SARS coronavirus helicase by bismuth complexes
The charges of Russian hacking and Mr Trump’s evident defects of experience, judgment and character show that the college has not proved the bulwark Mr Hamilton hoped for.
Total shipments of cellphones reached 560 million in 2016, up 8% year on year, the report showed.
8. Get Inspired
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Song “The Sacred Land” (Sun Nan)
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
《中国日报》(China Daily)援引中国旅游研究院(China Tourism Academy)和北京市旅游发展委员会(Beijing Commission of Tourism Development)的一篇报告称，污染状况加剧以及人民币升值，使得北京去年1月至11月间的外国游客数量从2012年同期的501万人下降至420万人。此前一份基于对国内旅行社的调查的报告显示，去年前三个季度赴北京旅游的游客数量较上年同期下降约50%。
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Imports grew 3.1 per cent year-on-year in dollar terms to $168.6bn in December after growing a revised 4.7 per cent (previously 6.7 per cent) the previous month. That rate was roughly in line with a median forecast of 3 per cent growth.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
ICBC’s earnings per share were Rmb0.77, down from Rmb0.78 last year, and a pre-tax dividend per share was Rmb0.2333, down from Rmb0.2554.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
6. Cutting Down on Saturated Fats Could Preserve Your Memory
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Until now Thor has been the neglected child of the Marvel Cinematic Universe. Though some liked Kenneth Branagh’s first film featuring the god of thunder, Chris Hemsworth was arguably overshadowed by Tom Hiddleston’s preening popinjay of a villain, Loki. And the second film, the humourless Thor: The Dark World, is widely regarded as the worst film released by Marvel Studios to date. So to inject new life into this sagging franchise, Marvel brought in New Zealand comedy auteur Taiki Waititi to add some Kiwi quirk. This time Thor faces down the goddess of death, played by Cate Blanchett. Thor may have the hammer, but she has the attitude. Released November 1 in Serbia and Hungary, November 2 in Cambodia and Israel and November 3 in India and Canada. (Credit: Marvel Studios)
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
According to the index, tourists are "spending overwhelmingly" to shop -- and not to dine -- in the top 20 destinations outside of Europe, despite many of them being world-famous cuisine capitals.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
2. Do I have too much clutter? Drowning ourselves in too many material possessions can ultimately lead to stress. Get clear on what you absolutely need and what you can get rid of.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
There are, for example, clear differences in the way the products are pitched to investors in the US and Asia. A high proportion — some estimate 90 per cent — of funds in Asia are commission-based. This disadvantages ETFs because they are openly traded on stock exchanges and are not structured to pay commissions to banks, brokerages or financial advisers that might recommend them, unlike the mutual fund industry in the region.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
The number of moviegoers in 2016 reached 1.37 billion, an increase of nearly 8.9 percent year-on-year.
According to the Chinese Academy of Social Sciences, China's migrant workers account for around 50 percent of the labor force in industrial and related sectors. Yet they don't enjoy equal rights as city dwellers because of household registration requirements.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
“We miss a heck of a lot of people,” Mr Hoogewerf told the Financial Times. “I was in Beijing two weeks ago and visited this investment company. In the space of one afternoon I discovered 30 people who went on to our rich list this year. Last year they were under our radar.”
You qualify as a type D personality if you scored 10 or higher on both Negative Affectivity and Social Inhibition scales.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
The Cnzz.com report also discusses the problem of the 'free-to-play' business model that's prevalent in China's online game sector. While many games companies in the U.S., for example, charge subscription fees, most Chinese games utilize the free-to-play model, which allows players to try out a game without paying. The longer players stay in the game, the more likely they will be to pay for in-game items to move up into higher levels of play. But that also means that people who spend the most money are the best performers.
May the glow of New Year candle fill your heart with peace and pleasure and make your New Year bright.
●"Woman arrested for defecating on boss’ desk after winning the lottery"
A modular microarray imaging system for highly specific COVID-19 antibody testing
Those falls came despite a rise in insurance premium income of 37.3 per cent year-on-year to Rmb1.88tn, while total assets reached Rmb14.27tn, up 15.4 per cent.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Frankly, this is unlikely to be ready in time for next year, but we'll include it just in case. The second film from Laszlo Nemes, who won the foreign language Oscar earlier this year for Son of Saul, is a coming-of-age drama set in Budapest just before the first world war.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Since 2005, the business book of the year award has gone to the book that provides “the most compelling and enjoyable insight into modern business issues”. The 2014 winner was Capital in the Twenty-First Century by Thomas Piketty.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Strachan says that he believes that the IP-BOX uses the same method employed by the FBI to unlock the iPhone 5c used by Syed Farook, without Apple's help. The FBI is now offering to help other law enforcement agencies seeking to unlock an iPhone, iPad or Apple iPod touch. Apple is trying to discover how the FBI unlocked the phone so that it can issue a software update to close the vulnerability.
The frame is easily assembled and attaches to paddle boards, kayaks, and rafts.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
On April 24, Zhou took the pesticide to the Yimin Technician Training School in Rongchang, Chongqing and hid the toxic substance under a desk.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
The year before, Taiwanese anti-China protesters chose the sunflower as the symbol for their cause.
A facile assay for rapid detection of COVID-19 antibodies
The book reflects growing anxiety in some quarters about the possible negative impact of automation on jobs, from manufacturing to professional services. The subtitle of its UK edition warns of “the threat of mass unemployment” and, in the US edition, foresees “a jobless future”.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
英国大选就是个教训。民调也不过是戛纳的“外卖餐点”：预测是傻瓜才干的事。一整周，坊间盛传托德?海因斯的女同性恋恋爱故事《卡罗尔》将斩获金棕榈最佳影片奖，或者拉斯洛?杰莱斯László Nemes 处女作《索尔的儿子》Son of Saul将折桂。最后几天，共识则是来自台湾的导演侯孝贤（Hou Hsiao-Hsien）指导的《刺客聂隐娘》（The Assassin）将问鼎大奖。且据英国博彩分析，《龙虾》是个难缠的对手。但是，最终宣布雅克?欧迪亚Jacques Audiard's 《流浪的迪潘》Dheepan获奖时，大家一致惊讶表示：“真的吗？”所有的评论员、影评人小组、内部八卦、数据统计、上帝都知道，只是少有人提及罢了。好吧，这就是生活。
China’s investment in Europe and the US has reached record highs, despite the slowdown in the country’s domestic economy.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
A New York City restaurant is taking a stab at creating the most decadent pizza on the market with a pie topped in gold flakes, foie gras and even truffles.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
The report shows Cases of dishonesty connected to e-commerce platforms and enterprises, logistics companies, third-party payment platforms and consumers in a five-day period from Nov 11 to 15 increased 57.49% compared to last year.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
10.I thought I already sent that email out. I’m sure I did. – Because telling you that it was a low priority and I forgot would probably hurt our relationship。
'I just want to stay professional. I don't want them to think I'm a fangirl. I'm one of the performers and I'm not just a background dancer, I'm the dancer.'
Length-scale dependence of protein hydration-shell density
Actress in a Mini-Series or Movie: Sarah Paulson, “The People v. O. J. Simpson: American Crime Story”
5.Bryan Cranston was a Murder Suspect
除了北方高等商学院和巴黎高等商学院以外，高等经济商业学院(Essec Business School)、巴黎高等商业学院-欧洲管理学院(ESCP Europe)和商科联盟国际商学院(Skema Business School)分列第三、第四和第六位。
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
The curbs are having an effect. Overall non-financial outbound investment fell 36 per cent in January from a year earlier to Rmb53bn ($7.8bn), the commerce ministry said on Thursday, following a 39 per cent drop in December.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
We will strengthen the prevention and control of water and soil pollution.
About this collection
14. On the Other Hand Here is an estimate of the movies directed by women that were released by major studios this year: Warner Bros. (five! — Lana Wachowski, Anne Fletcher, Dana Nachman, Nancy Meyers, Patricia Riggen); Universal (three — Sam Taylor Johnson, Elizabeth Banks, Angelina Jolie); Disney (one — Niki Caro); Paramount (0); Fox (0); and Sony (0). (I excluded Fox and Sony’s specialty units.)
Whether of left or right, they present themselves as representatives of the common people against elites and unworthy outsiders; make a visceral connection with followers as charismatic leaders; manipulate that connection for their own advancement, frequently by lying egregiously; and threaten established rules of conduct and constraining institutions as enemies of the popular will that they embody.